Causes of Aortic Dissection
The aorta has several different parts:
- Aortic root
- Ascending aorta
- Aortic arch
- Descending thoracic aorta
- Abdominal aorta
Aortic dissection can occur in any of these parts. Aortic dissections are classified according to the location of the initial aortic tear, and the parts of the aorta that are involved in the dissections. The two major classifications are the Stanford Classification and the DeBakey Classification.
Why do people get aortic dissection?
Aortic dissection may occur for several reasons, including genetics, chronic high blood pressure, high cholesterol, smoking, trauma, and illegal drug use.
Some people are born with an alteration in specific genes that affect development of the aortic wall and predispose the aorta to enlargement and/or dissection. Syndromes that are associated with certain genetic defects include:
- Familial Thoracic Aortic Aneurysm
A bicuspid aortic valve is a marker for a connective tissue syndrome and may be associated with valve problems, aortic root aneurysms, and ascending aortic aneurysms. These aneurysms have the potential to result in aortic dissection.
Chronically uncontrolled high blood pressure can put stress on the aortic wall over time and can lead to aneurysm and dissection. Patients with blood vessel disease related to years of high blood pressure, high cholesterol, and smoking can develop a calcification or ulcer of the aorta that may become the site where a dissection occurs.
The aorta also can dissect or rupture from trauma, such as during a high-speed motor vehicle accident or fall from a significant height. Additionally, cocaine and methamphetamine use can increase the likelihood of aortic dissection.
Diagnosis and Treatment Options
When aortic dissection is suspected based on your history and physical exam, time is of the essence. You usually will be sent for an emergent computed tomography (CT) scan with intravenous contrast (a dye injected via a vein) so that doctors can look at blood flow in your aorta.
If an aortic dissection is present, the CT scan will show blood flowing in the false channel and may show the part(s) of the aorta that is involved in the dissection. If you can’t get a CT scan, a transesophageal echocardiogram, where the ultrasound probe is placed in the esophagus behind the heart and aorta, sometimes is performed to look for the dissection in the ascending or descending thoracic aorta.
For more information on these tests, visit our common diagnostic tests page.
What are the treatment options?
When aortic dissection involves the aortic root or ascending aorta (Stanford Type A or DeBakey Types 1 and 2), the treatment is emergency surgery. This is because the risk of death from aortic rupture increases with every hour from the onset of symptoms. The patient should undergo emergent open heart surgery at the hospital where the dissection has been diagnosed or should be transferred to a hospital that performs the procedure.
The operation is done through an incision down the middle of the chest. The heart-lung machine is used to stop the heart and lungs. Sometimes the body temperature is cooled (to as low as 64° Fahrenheit) in order to temporarily stop blood flow so that the aortic arch, the part of the aorta that gives off the arteries to the arms and brain, can be repaired. The ascending aorta is replaced with a synthetic woven graft. Sometimes the aortic root and aortic valve need to be replaced, or all of the aortic arch needs to be replaced.
Possible complications after this operation include:
-Bleeding requiring transfusion or re-operation
-Being on the ventilator for several days or longer
When aortic dissection involves the descending thoracic aorta and/or the abdominal aorta, several different management strategies may be used. You may be monitored closely in an intensive care unit (ICU) with intravenous (IV) infusions of medications to aggressively lower your heart rate and blood pressure. This helps decrease stress on the aorta to prevent it from rupturing and also helps promote flow through the “cardboard tubing” rather than the “paper towel layers.”
You also may undergo an emergent or urgent procedure known as Thoracic Endovascular Aortic Repair (TEVAR), in which a stent graft, consisting of fabric sewn onto an expandable nitinol (nickel-titanium metal alloy) frame, is placed in the descending thoracic aorta to cover the intimal tear and prevent blood from flowing into the false channel.
Possible complications after this operation include:
-Temporary or permanent paralysis
-Bleeding complication from accessing the femoral arteries in the groin
-Kidney dysfunction or failure related to impaired blood flow to the kidney arteries from the dissection or related to the contrast given for the CT scan or the stent graft procedure
What is the recovery like after surgery?
For an ascending aortic dissection, the course and length of your recovery would depend on your condition at the time of surgery, the extent of the operation, and any post-operative complications. The hospital stay may vary from 5-7 days to 3-4 weeks.
For a medically managed dissection that involves the descending thoracic aorta and abdomen, your hospital stay would be 5-7 days to make sure that your blood pressure is well-controlled and the aorta is not changing on follow-up imaging. If the dissection is treated with a stent graft, the hospital stay could vary from 5-7 days to a few weeks, depending on whether you have post-operative complications such as leg weakness.
What happens after discharge from the hospital?
Regardless of what part of the aorta is involved, if you have an aortic dissection, you will need lifelong surveillance to monitor for post-operative complications or continued growth or change in the aorta. Surveillance imaging may include CT scans or magnetic resonance imaging (MRI). Follow-up is usually with a cardiothoracic surgeon who will review the imaging and determine what, if any, further procedures need to be performed.
You will need to have well-controlled blood pressure, which may require taking several medications. Modifying your activity or exercise is recommended, including avoiding heavy lifting and prolonged straining.
What can I do to prevent it?
If you or someone in your immediate family has been diagnosed with a genetic syndrome (Marfan, Ehlers-Danlos, Loeys-Dietz, familial thoracic aortic aneurysm, bicuspid aortic valve,) or you have a family history of thoracic aortic aneurysm or aortic dissection, you should see a cardiologist or cardiothoracic surgeon to undergo screening with CT angiography (CTA) to see if you have an aortic aneurysm.
If you have an aneurysm, this can be monitored appropriately or treated before aortic dissection occurs. Blood pressure control is important, and you should work with your primary care physician or cardiologist to adjust your medications in order to achieve this. Modifying your activities and exercise to avoid heavy weight lifting and prolonged straining is also recommended. Avoid smoking to prevent injury to the blood vessel wall of the aorta and its branches.
Reviewed by: Karen Kim, MD, and Robbin G. Cohen, MD, MMM